医学部
宁波大学 主任信箱 ENGLISH
师资队伍
生物化学与分子生物学系

姓名:LIM YOON PIN (林允斌)
职务:
职称:研究员
政治面貌:
最高学历学位:博士研究生
专业:分子细胞生物学
所属院系:生物化学与分子生物学系
研究方向:创新肿瘤生物标志物研究及药物研发
电话:
信箱:limyoonpin@nbu.edu.cn
个人主页:


个人简介

国家海外高层次引进专家、宁波大学包玉刚杰出人才。毕业于新加坡国立大学分子细胞学专业,拥有长期海外顶尖高校与科研机构工作经历。先后担任美国哈佛大学研究员;新加坡国立大学癌症分子与转化实验室主任、质谱中心主任;Oncotec Private Limited 公司首席科学家、高级总监;国科宁波生命与健康产业研究院特聘研究员、癌症精准医学研究创新中心主任。

兼任新加坡胃癌联盟成员、新加坡卫生部科学评审委员会委员。曾获新加坡国立大学长期服务奖、杨潞龄医学院教学卓越奖,新加坡国立大学卓越研究奖提名;先后荣获亚洲临床肿瘤学会最佳论文暨口头汇报奖、全球乳腺癌大会 — 韩国乳腺癌基金会国际奖、中国临床肿瘤学会 — 美国临床肿瘤学会旅行奖、英国剑桥 FASEB 蛋白激酶与蛋白磷酸化会议最佳摘要奖等多项重要学术荣誉。

长期致力于精准医学与抗癌药物研发领域研究,带领团队成功研制多款创新药物及诊断标志物。在《Clinical Cancer Research》《ACS Nano》《Cancer Research》《Oncogene》《EMBO Journal》《Journal of Clinical Investigation》等国际权威期刊发表学术论文 66 篇;拥有中国、美国、欧洲等国家和地区专利 14 项,其中 4 项专利已许可跨国公司及中小企业实现产业化转化。主持科研项目 11 项,经费累计 6000 万元;参与科研项目 9 项,经费累计 1.6 亿元。累计指导博士后 15 名、研究生 12 名、本科生 19 名、预科生 10 名,培养博士研究生 13 名。


学习和工作经历

(1) 学习经历

学校名称

学科

学位

新加坡国立大学

分子细胞生物学

博士学位

新加坡国立大学

微生物学与免疫学

学士学位

(2) 工作经历

时间

工作单位

职称

2023-02-至2026-02

国科宁波生命与健康产业研究院

研究员

2021-01至2022-12

Oncotec Pte Ltd

首席科学官

2004-09至2020-12

新加坡国立大学

研究员

2001-06至2004-09

新加坡国立癌症中心

研究员

1999-06至2001-06

哈佛医学院达纳-法伯癌症研究所

副研究员

近年发表的主要论文

总计发表66篇

代表性论文

1. Lin H, Kang SA, Xie F, Lim YX, Seah SH, Sabbaghian A, Lu SY, Chew TG, Deng LW, Wang S, Tai ES, Lim YP. WBP2 Attenuates Metformin Response in HER2-Positive Breast Cancer Cells by Repressing AMPK Activation and Inducing a Lower AMP:ATP Ratio State Through Enhanced ATP Production. Cells 2026 Feb 23;15(4):381 

2. Sabbaghian A, Xie F, Wang XF, Yang Z, Zhang MC, Chew TG, Wang S, Lim YP. WFIKKN2 is secreted and elevated in blood plasma of HER2-Positive Breast Cancer Patients – Implications in cancer surveillance and recurrence monitoring. Biomark Res 2025 Nov 5;13(1):142 

3. Sabbaghian A, Lin H, Lim YP. WBP2 and Its Network of Transcription Coregulators in an Expanding Repertoire of Human Cancers. Int. J. Cancer. 2026 Jan 1;158(1):218-231 

4. Sadeghi S, Masurkar ND, Vallerinteavide Mavelli G, Deshpande S, Kok Yong Tan W, Yee S, Kang SA, Lim YP, Kai-Hua Chow E, Drum CL. Bioorthogonal Catalysis for Treatment of Solid Tumors Using Thermostable, Self-Assembling, Single Enzyme Nanoparticles and Natural Product Conversion with Indole-3-acetic Acid. 2022 ACS Nano 16(7):10292-301. 

5. Hum M, Tan HJ, Yang, Y, Srivastava S, Teh Meng, Lim YP. WBP2 promotes gastric cancer cell migration via novel targeting of LATS2 kinase in the Hippo tumor suppressor pathway. 2021 FASEB J. Feb; 35(2):e21290. 

6. Lim SK, Tabatabaeian H, Lu S, Kang SA, Sundaram MG, Prabha S, Chan SW, Hong WJ, Lim YP. Hippo/MST Blocks Breast Cancer by Downregulating WBP2 Oncogene expression via miRNA processor Dicer. 2020 Cell Death Dis. 2020 Aug 21;11(8):669. 

7. Tabatabaeian H, Rao A, Ramos A, Chu T, Sudol M, Lim YP. The Emerging Roles of WBP2 Oncogene in Human Cancers. 2020 Oncogene 39:4621–4635

8. Kang SA, Guan JS, Tan HJ, Chu T, Thike AA, Bernado C, Arribas J, Wong CY, Tan PH, Gudi M, Putti TC, Sohn J, Lim SH, Lee SC and Lim YP. Elevated WBP2 expression in HER2-positive breast cancers correlates with sensitivity to trastuzumab-based neo-adjuvant therapy: A Retrospective and Multicentric Study. 2019 Clin. Cancer Res. 15;25(8):2588-2600

9. Li Z, Lim SK, Liang X, Lim YP. The transcriptional coactivator WBP2 primes triple-negative breast cancer cells for responses to Wnt signaling via the JNK/Jun kinase pathway. 2018 J. Biol. Chem. 293(52):20014-20028 

10. Lim SK, Lu S, Tan HJ, Li Z, Wee ZNA, Guan JS, Chichili VPR, Sivaraman J, Putti TC, Thike AA, Tan PH, Sudol M, Virshup DM, Chan SW, Hong WJ and Lim YP. Wnt Signaling Promotes Breast Cancer By Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2. Cancer Res. 2016 Nov 1; 76(21):6278-6289

近年主持/参与的项目

主持:

1. National Medical Research Council (NMRC) – Open Fund Individual Research Grant OF-IRG16nov012 - Two is better than one – Her2 in combination with WBP2 improves anti-Her2 precision medicine in breast cancer. SGD 879, 900.00

2. Ministry of Education Tier 2 Grant - MOE2016-T2-2-007 - Reversible Control of WBP2 Oncogene by Tumor Suppressors in breast cancer. SGD 560,426.

3. National Medical Research Council (NMRC) – Cooperative Basic Research Grant (CBRG) NMRC/CBRG/0013/2012 – Novel Drug Targets for Gastric Cancer Therapy. SGD 1, 167,750

4. A*STAR Biomedical Research Council (BMRC) 10/1/21/19/657. WBP2, a novel breast cancer oncogene & candidate for targeted therapeutics? SGD 750,000

5. A*STAR Exploit Technologies F09/X/037_c. DNA Aptamer Diagnostics for Cancer and Disease. SGD 933,000

参与:

1. National Medical Research Council (NMRC) -Translational and Clinical Program (TCR) – NMRC/TCR/001/2007. Co-investigator with Professor Yeoh Khay Guan along with 18 other co-investigators. - Singapore Gastric Cancer Consortium - Improving Outcomes for Our Patients. SGD 25 million。

2. National University Health System Summit Research Program (SRP). Co-I with Tai E-Shyong - Metabolic Disease. SGD 1, 897, 000.

3. National Medical Research Council (NMRC), Clinician Scientist Individual Research Grant (CS-IRF). Co-I with Peter Lobie - Generation of inhibitors to trefoil factor-3 for preclinical development in oncology. SGD 952, 149.


已获授权的发明专利

1. 林允斌; A method for determining plasma biomarker protein for breast cancer detection 用于乳腺癌检测的血浆生物标志物蛋白的测定方法, 2025-09-17, 中国, 202511326821.9.

2. 林允斌; WBP2与HER2作为共预后因子对患者分层进行治疗WBP2 as a Co-Prognostic Factor with Her2 for Stratification of Patients for Treatment, 2021-02-09, 中国, ZL 201680042719.9

3. Lim Yoon Pin; WBP2 as a Co-Prognostic Factor with Her2 for Stratification of Patients for Treatment, 2023-01-10, Singapore, 11201710409P

4. LIM YOON PIN; Novel Cancer Target And Biomarker, 2015-11-27, Singapore, 10201508307S

5. 林允斌; 酪氨酸磷酸化的WBP2 -一种新的癌症靶和生物标志物Tyrosine-Phosphorylated WBP2, A Novel Cancer Target and Biomarker, 2017-02-15,中国, ZL 201180051871.0

6. YOON PIN LIM; Tyrosine-Phosphorylated WBP2, A Novel Cancer Target and Biomarker, 2016-8-30, USA, 9429582

7. Lim Yoon Pin; Methods for Detection of Gastric Cancer, 2017-02-07, USA, 9562906.

8. Lim Yoon Pin; Protein Involved in Detection of Cancer Metastasis and a Treatment Thereof, 2016-06-07, USA, 9359423.

9. Lim Yoon Pin; Cancer Biomarker and The Use Thereof, 2014-03-11, USA, 8669067.

10. Lim Yoon Pin; Cancer Biomarker and The Use Thereof, 2014-10-22, European, 2457092.

11. Lim Yoon Pin; Cancer Biomarker and The Use Thereof, 2014-12-11, Germany, 60 2010 019 742.5

12. Lim Yoon Pin; Cancer Biomarker and The Use Thereof, 2014-10-23, United Kingdom, 2457092.

13. Lim Yoon Pin; Cancer Biomarker and The Use Thereof, 2014-11-21, France, 2457092.

14. Lim Yoon Pin; Cancer Biomarker and The Use Thereof, 2014-12-31, China, ZL201080042262.4

著作编写

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学术兼职

略


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生物化学与分子生物学系

姓名:LIM YOON PIN (林允斌)
职务:
职称:研究员
政治面貌:
最高学历学位:博士研究生
专业:分子细胞生物学
所属院系:生物化学与分子生物学系
研究方向:创新肿瘤生物标志物研究及药物研发
电话:
信箱:limyoonpin@nbu.edu.cn
个人主页:


个人简介

国家海外高层次引进专家、宁波大学包玉刚杰出人才。毕业于新加坡国立大学分子细胞学专业,拥有长期海外顶尖高校与科研机构工作经历。先后担任美国哈佛大学研究员;新加坡国立大学癌症分子与转化实验室主任、质谱中心主任;Oncotec Private Limited 公司首席科学家、高级总监;国科宁波生命与健康产业研究院特聘研究员、癌症精准医学研究创新中心主任。

兼任新加坡胃癌联盟成员、新加坡卫生部科学评审委员会委员。曾获新加坡国立大学长期服务奖、杨潞龄医学院教学卓越奖,新加坡国立大学卓越研究奖提名;先后荣获亚洲临床肿瘤学会最佳论文暨口头汇报奖、全球乳腺癌大会 — 韩国乳腺癌基金会国际奖、中国临床肿瘤学会 — 美国临床肿瘤学会旅行奖、英国剑桥 FASEB 蛋白激酶与蛋白磷酸化会议最佳摘要奖等多项重要学术荣誉。

长期致力于精准医学与抗癌药物研发领域研究,带领团队成功研制多款创新药物及诊断标志物。在《Clinical Cancer Research》《ACS Nano》《Cancer Research》《Oncogene》《EMBO Journal》《Journal of Clinical Investigation》等国际权威期刊发表学术论文 66 篇;拥有中国、美国、欧洲等国家和地区专利 14 项,其中 4 项专利已许可跨国公司及中小企业实现产业化转化。主持科研项目 11 项,经费累计 6000 万元;参与科研项目 9 项,经费累计 1.6 亿元。累计指导博士后 15 名、研究生 12 名、本科生 19 名、预科生 10 名,培养博士研究生 13 名。


学习和工作经历

(1) 学习经历

学校名称

学科

学位

新加坡国立大学

分子细胞生物学

博士学位

新加坡国立大学

微生物学与免疫学

学士学位

(2) 工作经历

时间

工作单位

职称

2023-02-至2026-02

国科宁波生命与健康产业研究院

研究员

2021-01至2022-12

Oncotec Pte Ltd

首席科学官

2004-09至2020-12

新加坡国立大学

研究员

2001-06至2004-09

新加坡国立癌症中心

研究员

1999-06至2001-06

哈佛医学院达纳-法伯癌症研究所

副研究员

近年发表的主要论文

总计发表66篇

代表性论文

1. Lin H, Kang SA, Xie F, Lim YX, Seah SH, Sabbaghian A, Lu SY, Chew TG, Deng LW, Wang S, Tai ES, Lim YP. WBP2 Attenuates Metformin Response in HER2-Positive Breast Cancer Cells by Repressing AMPK Activation and Inducing a Lower AMP:ATP Ratio State Through Enhanced ATP Production. Cells 2026 Feb 23;15(4):381 

2. Sabbaghian A, Xie F, Wang XF, Yang Z, Zhang MC, Chew TG, Wang S, Lim YP. WFIKKN2 is secreted and elevated in blood plasma of HER2-Positive Breast Cancer Patients – Implications in cancer surveillance and recurrence monitoring. Biomark Res 2025 Nov 5;13(1):142 

3. Sabbaghian A, Lin H, Lim YP. WBP2 and Its Network of Transcription Coregulators in an Expanding Repertoire of Human Cancers. Int. J. Cancer. 2026 Jan 1;158(1):218-231 

4. Sadeghi S, Masurkar ND, Vallerinteavide Mavelli G, Deshpande S, Kok Yong Tan W, Yee S, Kang SA, Lim YP, Kai-Hua Chow E, Drum CL. Bioorthogonal Catalysis for Treatment of Solid Tumors Using Thermostable, Self-Assembling, Single Enzyme Nanoparticles and Natural Product Conversion with Indole-3-acetic Acid. 2022 ACS Nano 16(7):10292-301. 

5. Hum M, Tan HJ, Yang, Y, Srivastava S, Teh Meng, Lim YP. WBP2 promotes gastric cancer cell migration via novel targeting of LATS2 kinase in the Hippo tumor suppressor pathway. 2021 FASEB J. Feb; 35(2):e21290. 

6. Lim SK, Tabatabaeian H, Lu S, Kang SA, Sundaram MG, Prabha S, Chan SW, Hong WJ, Lim YP. Hippo/MST Blocks Breast Cancer by Downregulating WBP2 Oncogene expression via miRNA processor Dicer. 2020 Cell Death Dis. 2020 Aug 21;11(8):669. 

7. Tabatabaeian H, Rao A, Ramos A, Chu T, Sudol M, Lim YP. The Emerging Roles of WBP2 Oncogene in Human Cancers. 2020 Oncogene 39:4621–4635

8. Kang SA, Guan JS, Tan HJ, Chu T, Thike AA, Bernado C, Arribas J, Wong CY, Tan PH, Gudi M, Putti TC, Sohn J, Lim SH, Lee SC and Lim YP. Elevated WBP2 expression in HER2-positive breast cancers correlates with sensitivity to trastuzumab-based neo-adjuvant therapy: A Retrospective and Multicentric Study. 2019 Clin. Cancer Res. 15;25(8):2588-2600

9. Li Z, Lim SK, Liang X, Lim YP. The transcriptional coactivator WBP2 primes triple-negative breast cancer cells for responses to Wnt signaling via the JNK/Jun kinase pathway. 2018 J. Biol. Chem. 293(52):20014-20028 

10. Lim SK, Lu S, Tan HJ, Li Z, Wee ZNA, Guan JS, Chichili VPR, Sivaraman J, Putti TC, Thike AA, Tan PH, Sudol M, Virshup DM, Chan SW, Hong WJ and Lim YP. Wnt Signaling Promotes Breast Cancer By Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2. Cancer Res. 2016 Nov 1; 76(21):6278-6289

近年主持/参与的项目

主持:

1. National Medical Research Council (NMRC) – Open Fund Individual Research Grant OF-IRG16nov012 - Two is better than one – Her2 in combination with WBP2 improves anti-Her2 precision medicine in breast cancer. SGD 879, 900.00

2. Ministry of Education Tier 2 Grant - MOE2016-T2-2-007 - Reversible Control of WBP2 Oncogene by Tumor Suppressors in breast cancer. SGD 560,426.

3. National Medical Research Council (NMRC) – Cooperative Basic Research Grant (CBRG) NMRC/CBRG/0013/2012 – Novel Drug Targets for Gastric Cancer Therapy. SGD 1, 167,750

4. A*STAR Biomedical Research Council (BMRC) 10/1/21/19/657. WBP2, a novel breast cancer oncogene & candidate for targeted therapeutics? SGD 750,000

5. A*STAR Exploit Technologies F09/X/037_c. DNA Aptamer Diagnostics for Cancer and Disease. SGD 933,000

参与:

1. National Medical Research Council (NMRC) -Translational and Clinical Program (TCR) – NMRC/TCR/001/2007. Co-investigator with Professor Yeoh Khay Guan along with 18 other co-investigators. - Singapore Gastric Cancer Consortium - Improving Outcomes for Our Patients. SGD 25 million。

2. National University Health System Summit Research Program (SRP). Co-I with Tai E-Shyong - Metabolic Disease. SGD 1, 897, 000.

3. National Medical Research Council (NMRC), Clinician Scientist Individual Research Grant (CS-IRF). Co-I with Peter Lobie - Generation of inhibitors to trefoil factor-3 for preclinical development in oncology. SGD 952, 149.


已获授权的发明专利

1. 林允斌; A method for determining plasma biomarker protein for breast cancer detection 用于乳腺癌检测的血浆生物标志物蛋白的测定方法, 2025-09-17, 中国, 202511326821.9.

2. 林允斌; WBP2与HER2作为共预后因子对患者分层进行治疗WBP2 as a Co-Prognostic Factor with Her2 for Stratification of Patients for Treatment, 2021-02-09, 中国, ZL 201680042719.9

3. Lim Yoon Pin; WBP2 as a Co-Prognostic Factor with Her2 for Stratification of Patients for Treatment, 2023-01-10, Singapore, 11201710409P

4. LIM YOON PIN; Novel Cancer Target And Biomarker, 2015-11-27, Singapore, 10201508307S

5. 林允斌; 酪氨酸磷酸化的WBP2 -一种新的癌症靶和生物标志物Tyrosine-Phosphorylated WBP2, A Novel Cancer Target and Biomarker, 2017-02-15,中国, ZL 201180051871.0

6. YOON PIN LIM; Tyrosine-Phosphorylated WBP2, A Novel Cancer Target and Biomarker, 2016-8-30, USA, 9429582

7. Lim Yoon Pin; Methods for Detection of Gastric Cancer, 2017-02-07, USA, 9562906.

8. Lim Yoon Pin; Protein Involved in Detection of Cancer Metastasis and a Treatment Thereof, 2016-06-07, USA, 9359423.

9. Lim Yoon Pin; Cancer Biomarker and The Use Thereof, 2014-03-11, USA, 8669067.

10. Lim Yoon Pin; Cancer Biomarker and The Use Thereof, 2014-10-22, European, 2457092.

11. Lim Yoon Pin; Cancer Biomarker and The Use Thereof, 2014-12-11, Germany, 60 2010 019 742.5

12. Lim Yoon Pin; Cancer Biomarker and The Use Thereof, 2014-10-23, United Kingdom, 2457092.

13. Lim Yoon Pin; Cancer Biomarker and The Use Thereof, 2014-11-21, France, 2457092.

14. Lim Yoon Pin; Cancer Biomarker and The Use Thereof, 2014-12-31, China, ZL201080042262.4

著作编写

略


学术兼职

略


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